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E578 · Sequestrants

Calcium gluconate

No known risk

Calcium salt, firming agent.

Category
Sequestrants
Vegan
Yes
Vegetarian
Yes

What it is

A salt of gluconic acid used as a gentle acidity regulator, curing agent, or mineral supplement.

How it is used in food

In meat products like salami, it steadily lowers the pH to cure the meat safely without a sharp, overpowering sour taste.

Commonly found in
  • Cured meats
  • Tofu
  • Baked goods
  • Dairy products

Health and safety

Very safe. Broken down into glucose in the human digestive system.

Evaluated by EFSA and confirmed safe for use in food at authorized levels.

Regulatory status

RegionStatusNotes
Australia & New Zealand
FSANZ
Permitted Permitted under the FSANZ Food Standards Code.
European Union
EFSA / European Commission
Permitted Authorised for food use under EU regulations (Annex II).
United States
FDA (Food and Drug Administration)
Permitted Authorised for food use by the FDA (often GRAS for standard additives).

Identification on labels

E-number
E578

Worth knowing

Glucono-delta-lactone (GDL, E575) is widely used in making tofu to curdle the soy milk evenly.

Conclusion

There is no reason to avoid this calcium salt when it appears in your food. Because it simply breaks down into glucose once inside the human digestive system, EFSA considers it very safe for widespread use. It acts as a gentle firming agent and acidity regulator without introducing any health risks.

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Entry last reviewed 2026-07-28.

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