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E338 · Antioxidants, Sequestrants

Phosphoric acid

Moderate risk acidity regulator

Cola acid; high phosphate intake linked to cardiovascular concerns.

Category
Antioxidants, Sequestrants
Acceptable daily intake
40 mg/kg body weight/day (EFSA)
Vegan
Yes
Vegetarian
Yes

What it is

Phosphoric acid (E338) is a synthetic, mineral-based acid. It provides a sharp, tart flavor that is cheaper and more pungent than citric acid.

How it is used in food

Gives cola its sharp bite.

Commonly found in
  • Cola beverages and dark sodas
  • Processed cheese
  • Flavored waters and energy drinks

Health and safety

High total phosphate load is linked to vascular and kidney strain.

Phosphoric acid is the most asked-about ingredient in soft drinks. Like other synthetic phosphates (e.g., E450), the phosphorus in E338 is absorbed by the body at nearly a 100% rate, compared to the 40-60% absorption rate of natural phosphorus found in food.

Cardiovascular strain and bone loss

high consumers of cola, kidney patients · evidence: probable

High blood phosphate levels cause calcium to leach from bones, weakening them, and depositing the calcium into blood vessels, which stiffens arteries.

EFSA re-evaluation of phosphates

Dental erosion

general population · evidence: established

Because it is a strong acid, excessive exposure (like frequent soda consumption) actively erodes tooth enamel.

EFSA’s 2019 re-evaluation warned high consumers can exceed the safe intake.

Regulatory status

RegionStatusNotes
Australia & New Zealand
FSANZ
Permitted Permitted.
European Union
EFSA / European Commission
Permitted Authorised for food use under EU regulations (Annex II).
United States
FDA (Food and Drug Administration)
Permitted GRAS (Generally Recognized as Safe).

Identification on labels

E-number
E338

Also printed asOrthophosphoric acid

Alternatives to this additive

  • E330: Citric acid — A safer, naturally occurring acid, though it lacks the specific "bite" that defines a cola's flavor.

How it is made

It is industrially produced from mined phosphate rock. The rock is treated with sulfuric acid to produce phosphoric acid.

  1. Mining — Phosphate rock is mined.
  2. Acidulation — The rock is treated with sulfuric acid in the "wet process" to yield phosphoric acid.

Worth knowing

Can be used to remove rust.

Conclusion

A diet high in colas and processed foods can lead to excessive phosphate intake. This disrupts the body's calcium-phosphorus balance, forcing it to pull calcium out of bones, leading to decreased bone density and calcification (stiffening) of the arteries.

References

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Entry last reviewed 2026-07-28.

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