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E580 · Acidity regulators

Magnesium gluconate

No known risk

A safe and highly bioavailable magnesium supplement.

Category
Acidity regulators
Vegan
Yes
Vegetarian
Yes

What it is

A magnesium salt of gluconic acid used as a highly bioavailable magnesium supplement.

How it is used in food

Doubles as an acidity regulator and a well-tolerated magnesium fortificant; the gluconate form is gentle on the stomach and among the better-absorbed magnesium salts used in foods and supplements.

Commonly found in
  • Dietary supplements

Health and safety

Completely safe and serves as a healthy source of dietary magnesium.

Safety assessments of both the magnesium and gluconate components report no concerns at dietary levels — gluconate is metabolised like carbohydrate and magnesium is an essential nutrient. As with all magnesium salts, the only practical limit is the osmotic laxative effect of multi-gram doses, and EU supplement guidance reflects that threshold rather than any toxicity.

Regulatory status

RegionStatusNotes
Australia & New Zealand
FSANZ
Permitted Permitted under the FSANZ Food Standards Code.
European Union
EFSA / European Commission
Not approved Not on the EU authorised list of food additives (Annex II).
United States
FDA (Food and Drug Administration)
Permitted Authorised for food use by the FDA (often GRAS for standard additives).

Identification on labels

E-number
E580

Worth knowing

Comparative absorption studies in animals have ranked magnesium gluconate at or near the top of common magnesium salts for bioavailability, which is why a food-additive code moonlights as a clinician-recommended supplement form.

Conclusion

A safe and highly bioavailable magnesium supplement.

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Entry last reviewed 2026-07-28.

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