ScanWise
E623 · Flavour enhancers

Calcium diglutamate

Limited risk

A common umami enhancer; safe unless you have specific glutamate sensitivities.

Category
Flavour enhancers
Vegan
Yes
Vegetarian
Yes

What it is

The calcium salt of glutamic acid, functioning like MSG to enhance savory (umami) flavors.

How it is used in food

Delivers the same umami flavour boost as MSG while contributing calcium instead of sodium, making it useful in low-sodium and salt-reduced products where taste normally suffers.

Commonly found in
  • Soups
  • Sauces
  • Snack foods

Health and safety

Safe for most, but some individuals may experience "MSG symptom complex" sensitivities.

EFSA re-evaluated glutamic acid and its salts (E620–E625) in 2017, setting a group ADI of 30 mg/kg body weight per day. Controlled double-blind studies have failed to reproducibly confirm 'MSG symptom complex' at normal dietary doses, though transient symptoms in some sensitive individuals at large doses taken without food cannot be fully excluded.

Regulatory status

RegionStatusNotes
Australia & New Zealand
FSANZ
Permitted Permitted under the FSANZ Food Standards Code.
European Union
EFSA / European Commission
Permitted Authorised for food use under EU regulations (Annex II).
United States
FDA (Food and Drug Administration)
Permitted Authorised for food use by the FDA (often GRAS for standard additives).

Identification on labels

E-number
E623

Worth knowing

Glutamate receptors on the tongue cannot tell these salts apart — calcium diglutamate, MSG and the glutamate naturally abundant in Parmesan, tomatoes and breast milk all trigger the identical umami signal.

Conclusion

A common umami enhancer; safe unless you have specific glutamate sensitivities.

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Entry last reviewed 2026-07-28.

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