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E629 · Flavour enhancers

Calcium guanylate

No known risk

An effective umami booster, but gout sufferers should be mindful.

Category
Flavour enhancers
Vegan
maybe
Vegetarian
maybe

What it is

The calcium salt of guanylic acid, used to enhance savory flavors in low-sodium foods.

How it is used in food

The calcium salt of guanylic acid delivers strong umami enhancement in low-sodium formulations, since it boosts savoriness without adding sodium.

Commonly found in
  • Low-sodium savory snacks
  • Soups

Health and safety

Safe, though it adds to total purine intake.

Covered by JECFA's group evaluation of 5'-guanylates, which concluded they are safe and assigned no numerical ADI. As a purine source, it is only a consideration for people managing gout or uric acid levels.

Regulatory status

RegionStatusNotes
Australia & New Zealand
FSANZ
Permitted Permitted under the FSANZ Food Standards Code.
European Union
EFSA / European Commission
Permitted Authorised for food use under EU regulations (Annex II).
United States
FDA (Food and Drug Administration)
Permitted Authorised for food use by the FDA (often GRAS for standard additives).

Identification on labels

E-number
E629

Worth knowing

On its own it has little taste — its power comes from synergy: combined with glutamate it can amplify perceived umami many times over.

Conclusion

An effective umami booster, but gout sufferers should be mindful.

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Entry last reviewed 2026-07-28.

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